End-product control of expression of branched-chain amino acid biosynthesis genes in Streptomyces coelicolor A3(2): paradoxical relationships between DNA sequence and regulatory phenotype
Article Abstract:
Branched-chain amino acid biosynthesis genes in Streptomyces coelicolor A3(2) are discussed relative to end-product control of their expression. Paradoxical relationships have been observed between DNA sequence and the regulatory phenotype. The branched-chain protein amino acids of interest are leucine, isoleucine and valine and they can give precursors for synthesis of complex polyketide secondary metabolites in streptomycetes.
author: Baumberg, Simon, Potter, Chris A., Craster, Heather L.
Publisher: Society for General Microbiology
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1999
United Kingdom, Genetic regulation, Genetic transcription, Transcription (Genetics), Biosynthesis, Leucine, Branched chain amino acids, Isoleucine
Genes encoding acyl-CoA dehydrogenase (AcdH) homologues from Streptomyces coelicolor and Streptomyces avermitilis provide insights into the metabolism of small branched-chain fatty acids and macrolide antibiotic production
Article Abstract:
Genes encoding acyl-CoA dehydrogenase (AcdH) homologues from Streptomyces avermitilis and Streptomyces coelicolor are discussed. They give insights into metabolism of macrolide antibiotic production and small branched-chain fatty acids. S. coelicolor and S. avermitilis genes encoding an acyl-CoA dehydrogenase thought to be involved in the catabolism of branched-chain amino acids were cloned.
author: Hutchinson, C. Richard, Zhang, Ting-Xin, Denoya, Claudio D., Skinner, Deborah D., Fedechko, Ronald W., McArthur, Hamish A.I., Morgenstern, Margaret R., Davies, Richard A., Lobo, Sandra, Reynolds, Kevin A.
Publisher: Society for General Microbiology
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1999
United States, Isotopes, Biology, Amino acids, Radioactive tracers, Radioactive tracers in biology
Involvement of amfC in physiological and morphological development in Streptomyces coelicolor A3(2)
Article Abstract:
The roles of amfC, which plays a regulatory role in aerial mycelium formation in Streptomyces griseus, in morphological and physiological development in Streptomyces coelicolor A3(2) are discussed. Disrupting the chromosomal amfC gene in S. coelicolor A3(2) greatly reduces formation of aerial hyphae.
author: Horinouchi, Sueharu, Ohnishi, Yasuo, Yonekawa, Tohru
Publisher: Society for General Microbiology
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1999
Japan, Antibiotics, Physiological aspects, Spores (Bacteria), Bacterial spores, Morphology (Biology), Microorganisms, Organic pigments
subjects list: Statistical Data Included, Research, Genetic aspects, Streptomyces, Cytochemistry, Usage, Chromosome mapping
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