Bovine rotavirus nonstructural protein 4 produced by Lactococcus lactis is antigenic and immunogenic

Article Abstract:

Researchers have genetically engineered Lactococcus lactis to produce rotavirus nonstructural protein 4 (NSP4). NSP4 is believed to be an enterotoxin produced by rotavirus, which is a major cause of diarrhea in babies and children.

author: Corthier, Gerard, Langella, Philippe, Enouf, Vincent, Commissaire, Jacqueline, Cohen, Jean
Microbial genetic engineering, Endotoxins, Rotaviruses

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Lactococcus lactis SpOx spontaneous mutants: A family of oxidative-stress-resistant dairy strains

Article Abstract:

Spontaneous oxidative-stress-resistant (SpOx) Lactococcus lactis mutants are isolated using a natural selection method with milk-adapted strains on dairy culture medium containing H2O2. The results revealed that the three SpOx mutants displayed greater H2O2 resistance.

author: Corthier, Gerard, Langella, Philippe, Gruss, Alexandra, Rochat, Tatiana, Gratadoux, Jean-Jacques, Coqueran, Berard, Nader-Macias,, Maria-Elena
Argentina, Oxidative stress

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Effects of intranasal administration of a leptin-secreting lactococcus lactis recombinant on food intake, body weight, and immune response of mice

Article Abstract:

An L. lactis strain is designed for highly efficient secretion of biologically active leptin. Biological activity of the leptin produced by L. lactis also demonstrated in vivo in mice.

author: Corthier, Gerard, Langella, Philippe, Gruss, Alexandra, Nouaille, Sebastien, Bermudez-Humaran, Luis G., Zilberfarb, Vladimir, Issad, Tarik
Physiological aspects, Genetic aspects, Leptin

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subjects list: Research, Lactococcus
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