ESCRT-I core and ESCRT-II glue domain structures reveal role glue in linking to ESCRT-I and membranes

Article Abstract:

The yeast ESCRT-I links directly to ESCRT-II, through a tight interaction of Vps28 (ESCRT-I) with the yeast-specific zinc finger insertion with the GLUE domain of Vps36 (ESCRT-II). The crystal structure of the GLUE domain missing this insertion reveals it is a split PH domain, with a noncanonical lipid binding pocket that binds Ptdins3P.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

Article Abstract:

Results demonstrate that the Ras activation of phosphoinositide 3-kinase gamma is brought about by positioning Ras by a loop in the binding domain such that the enzyme binds to switch I and II regions of Ras. Data suggest that the same interactions may occurr in the alpha-form-Ras binding.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

Structural insight into the mechanism of double-stranded RNA processing by Ribonuclease IIIX

Article Abstract:

The crystal structure of an RNase III-product complex, the first catalytic complex observed for the family is presented. The structure reveals a wealth of information about the mechanism of RNA hydrolysis that can be extrapolated to other RNase III family members.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code: