ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway

Article Abstract:

ECSIT, for 'evolutionarily conserved signaling intermediate in Toll pathways,' is discussed. It is an intermediate in the Toll/IL-1 signal transduction pathway and is evolutionarily conserved. This adapter protein bridges TRAF6 to MEKK-1, is a regulator of MEKK-1 (mitogen-activated protein kinase/ERK kinase kinase-1) processing and seems to be important in signaling to NF-kappaB, the activation of which, a consequence of signaling through the Toll and IL-1 receptors, is a major element of innate immune responses. NF-kappaB is a general term that refers to homo- or heterodimers of the Rel family of proteins pre-existing in cytoplasm of most cells in an inactive state.

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Ecsit-ement on the crossroads of Toll and BMP signal transduction

Article Abstract:

Ecsit indicate a signaling node intersecting the pathways downstream of Toll-like receptors (TLR) and receptors for transforming growth factor-beta (TGF-beta) superfamily members. The findings of Xiao et al. (2003) provide a new molecular link between TLR and bone morphogenetic proteins (BMP) signaling pathways involving the adaptor protein Ecsit.

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Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis

Article Abstract:

The role of Ecsit as a cofactor for Smad proteins in the bone morphogenetic proteins (Bmps) signaling pathway is described. Bmps, members of the transforming growth factor beta (TGF beta) superfamily play important roles during mouse embryogenesis.

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