E2f3 is critical for normal cellular proliferation

Article Abstract:

E2f3, a family of transcription factors regulating cellular proliferation and differentiation, is critical for normal cell proliferation. An E2f3 mutant mouse strain was generated and found to arise at a quarter of the expected frequency. Embryonic fibroblasts from the mutant mice were analyzed. The mutation greatly impairs mitogen-induced transcription activation of cdc2, cdc6 and DHFR. A critical threshold level of one or more of the E2F3-regulated genes determines timing of the G(sub.1)/S transition, rate of DNA synthesis and thus rate of cell proliferation. E2F3 is not necessary for cell immortality but is rate limiting for proliferation of the tumor cell lines that arise from it.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos

Article Abstract:

The E2F transcription factors control gene expression mediating DNA-replication and cell cycle regulation involved in the cellular proliferation process. Research demonstrates that besides E2F1, E2F3 also contributes to the apoptosis and cell proliferation in a significant way.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics

Article Abstract:

E2F that directly participates in the transcriptional control of Arf in both normal and transformed cells is shown. It is proposed that monitoring of E2F levels and activity is a key component of Arf's ability to respond to inappropriate, but not cellular proliferation.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code: