Article Abstract:
A cellular receptor known as E-adhering is proven to mediate the entry of gram-positive bacteria into cells that are non-phagocytotic. Results of affinity chromatography show that E-cadherin is the ligand for internalin, which is known to be essential for epithelial cell entry. Morever, the results also show that the use of E-cadherin's chicken homolog in transfected fibroblasts leads to higher entry levels of Listeria monocytogenes. While the use of this homolog can also promote recombinant L. innocua, it does not promote entry of the wild-type noninvasive L. innocua.
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Article Abstract:
Zymogens destined to reside in lysosomes are transported to this organelle via two mannose 6-phosphate receptor (MPR) which are members of the P-type family of lectins found in animals. The three-dimensional structure of one of these MPRs, the cation-dependent MPR (CD-MPR) from cows, has been shown to crystallize in a dimeric structure with unit folding into a beta barrel consisting of nine strands. CD-MPR bears remarkable similarities with avidin.
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Article Abstract:
The cleavage of the Notch receptor on the plasma membrane occurs in the trans-Golgi network as the receptor traffics toward the plasma membrane. The Notch does not reach the surface even though full-length Notch is observable in the cell. The cleavage forms a C-terminal fragment and an N-terminal fragment. These fragments are tethered together on the plasma membrane by a link that is sensitive to reducing conditions.
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