Article Abstract:
Researchers have been able to establish that BRCA1/Rad51/BARD1 containing S phase nuclear foci are sensitive to the integrity of the genome. They are subject to significant structural change when exposed to genotoxic insult. BRCA1 seems to relocalize to replicating DNA structures after DNA damage, but the significance of this has not yet been established. It is possible that BRCA1 plays a role in DNA repair, and it could be fully bifunctional, acting as both a factor in the processing of abnormal DNA structures and taking part in the signaling which prompts the activation of genes following DNA damage.
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Article Abstract:
The BRCA1 and Rad51 proteins were observed to colocalize in vivo and to coimmunoprecipitate. BRCA1 residues 758-1064 alone formed Rad51-containing complexes in vitro. Rad51 is also specifically associated with developing synaptonemal complexes in meiotic cells and BRCA1 and Rad51 were both found on asynapsed elements of human synaptonemal complexes. Therefore, there is a possible functional interaction between BRCA1 and Rad51 in the meiotic and mitotic cell cycles.
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Article Abstract:
Results of several studies have provided information on the cellular pathways that may be affected by alterations in the breast cancer susceptibility genes BRCA1 and BRCA2. BRCA1 and BRCA2 have been associated with components of DNA damage response pathways resulting from their interaction with human RAD51. Moreover, BRCA1 and BRCA2 respond to DNA damage in several ways, including colocalization, similarities in the chromosomal abnormalities and maintenance.
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