Two enhancers and one silencer located in the introns of regA control somatic cell differentiation in Volvox carteri

Article Abstract:

Research shows that germ-soma differentiation in Volvox carteri is regulated by regA gene whose expression in somatic cells is dependent on introns 3 and 5 and involvement of intron 7 as a silencer of regA in gonidia. Data suggest that the silencer intron 7 functions as a cell-type-specific and promoter-specific enhancer.

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Phospholipase C gamma-1 is required downstream of vascular endothelial growth factor during arterial development

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Research has been conducted on artery formation. The authors have utilized transgenic zebrafish with fluorescently labeled blood vessels to identify and characterize the mutant displaying specific defects in artery formation, and have described the results.

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Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2

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Research has been conducted on Akt1 and Akt2 double-knockout mice which exhibit growth deficiency, impaired skin development and severe muscle atrophy. The authors suggest that Akt may be the most critical downstream effector of the IGF-1 receptor during development.

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