Article Abstract:
A hairy-related transcriptional repressor and its coregulation of anterior and posterior mesendodermal development are discussed. Recent research has found the first model for vertebrate endoderm patterning where an early regulatory step at gastrulation, mediated by her5 controls cell contribution to the two regions jointly.
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Article Abstract:
Drosophila homologs of transcriptional mediator complex subunits have been shown to be essential for adult segment and cell identity specification. The Drosophila homologs of 23 human mediator genes and mutations of two have ben identified. A general role for dTRAP80 required for cell viability is shown through clonal analysis. The dTRAP240 gene is required, but cells without its function are viable and they proliferate in a normal way.
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Article Abstract:
Various molecular mechanisms in the developmentally regulated transcription factor can be studied by examination of simple combinatorial rules for the regulation of the sloppy-paired-1 (slp 1) gene by the pair-rule transcription factors during Drosophila embryogenesis. Results indicate that developmentally regulated transcriptional elongation is central to the process of cell fate specification during the process of embryonic development.
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