Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles

Article Abstract:

A study revealed that Drosophila conserved eukaryotic gene fizzy-related regulates cyclin A, B and B3 levels negatively. The cdk1 binding and activating mitotic cyclins were found to degrade rapidly during G1 and when exiting from M. Results also show that fizzy-related loss induces salivary gland endoreduplication inhibition as well as progression through an additional division cycle in the epidermis.

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Identification of a Stat gene that functions in Drosophila development

Article Abstract:

A Drosophila Stat gene was identified. This gene encodes the signal transducers and activators of transcription (STAT) proteins, which function in cellular signal transduction and activate transcription. Phosphorylation studies showed that this STATs play an important role in segmental pattern formation during Drosophila early development by activating specific stripes of pair rule gene expression.

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Independent regulation of synaptic size and activity by the anaphase-promoting complex

Article Abstract:

A novel postmitotic role for the anaphase-promoting complex/cyclosome (APC/C) at Drosophila neuromuscular synapses is described. In neurons, the APC/C controls synaptic size through a downstream effector Liprin-alpha, and in muscles it controls the concentration of a postsynaptic glutamate receptor.

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