Divergence of melanocortin pathways in the control of food intake and energy expenditure
Article Abstract:
A loxP-modified, null melanocortin-4-receptors (MC4R) allele that can be reactivated by Cre-recombinanse is generated to identify the functionality relevant sites of MC4R expression. The findings reveal that MC4Rs in the paraventricular nucleus of the hypothalamus and/or the amygdala control food intake but that MC4Rs elsewhere control energy expenditure.
author: Lowell, Bradford B., Boss, Olivier, Elmquist, Joel K., Williams, Todd, Balthasar, Nina, Dalgaard, Louise T., Mountjoy, Kathleen, Kishi, Toshiro, Lee, Charlotte E., Jia Yu, Funahashi, Hisayuki, Ferreira, Manuel, Tang, Vinsee, McGovern, Robert A., Kenny, Christopher D., Christiansen, Lauryn M., Edelstein, Elizabeth, Aschkenasi, Carl, Chen-yu Zhang
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
Energy metabolism, Bioenergetics, Hypothalamus, Amygdala (Brain)
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1 alpha null mice
Article Abstract:
PGC-alpha is a coactivator of nuclear receptors and other transcription factors that regulates several metabolic processes, including mitochondrial biogenesis and respiration, hepatic gluconeogenesis, and muscle fiber-type switching. The central role for PGC-1 alpha in the control of energy metabolism is illustrated.
author: Lowell, Bradford B., Spiegelman, Bruce M., Cooper, Marcus P., Mootha, Vamsi K., Shulman, Gerald I., Wu, Zhidan, St-Pierre, Julie, Lin, Jiandie, Lindenberg, Katrin S., Fan, Melina C., Zavacki, Ann Marie, Rohas, Lindsay M., Jager, Sibylle, Zhang, Chen-yu, Krainc, Dimitri, Cinti, Saverio, Tarr, Paul T., Wu, Pei-Hsuan
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
Genetic transcription, Transcription (Genetics), Origin of life, Gluconeogenesis
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes
Article Abstract:
Research has been conducted on the beta cell sense glucose which stimulates insulin secretion. The role of the uncoupling protein-2 in regulating insulin secretion has been investigated and the results are reported.
author: Lowell, Bradford B., Peroni, Odile, Boss, Olivier, Shulman, Gerald I., Zhang, Chen-Yu, Baffy, Gyorgy, Perret, Pascale, Krauss, Stefan, Grujic, Danica, Hagen, Thilo, Vidal-Puig, Antonio J., Kim, Young-Bum, Zheng, Xin Xiao, Wheeler, Michael B., Chan, Catherine B.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
United States, Canada, Analysis, Causes of, Physiological aspects, Obesity, Type 2 diabetes, Proteins, Secretion, Cell research, Cytological research, Insulin, Pancreatic beta cells
subjects list: Research
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