Distinct functions of junD in cardiac hypertrophy and heart failure

Article Abstract:

Cardiac hypertrophic stimuli induce both adaptive and maladaptive growth response pathways in heart. A study showing that the mice lacking junD develop less adaptive hypertrophy in heart after mechanical pressure overload, while cardiomyocyte-specific expression of junD in mice results in spontaneous ventricular dilation and decreased contractility is detailed.

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c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity

Article Abstract:

Partial hepatectomy (PH) experiments in several double-knockout mouse models are performed to genetically identify the signaling events regulated by the activator protein 1 (AP-1) transcription factor c-Jun. The results demonstrate that c-Jun/AP-1 regulates liver regeneration through a molecular pathway that involves p53, p21, and the stress kinase p38alpha.

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Liver tumor development: c-Jun antagonizes the proapoptotic activity of p53

Article Abstract:

Research has been conducted on transcription factor c-Jun which mediates cell survival and proliferation. Results demonstrate that c-Jun prevents apoptosis via antagonizing p53 activity possibly contributing to the early stages of human hepatocellular carcinoma development.

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