Distinct functions of homeodomain-containing and homeodomain-less isoforms encoded by homothorax

Article Abstract:

The alternative splicing of homothorax (hth) is shown, which generates two types of protein isoforms, the first that contains a DNA-containing homoeodomain (HthFL) and the other, that does not contain a homoedomain (HDless). It is further demonstrated that the mouse ortholog of hth, Meis1, also encodes a HDless isoform, suggesting that homoedomain-less variant of this gene family are evolutionarily ancient.

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Proneural gene self-stimulation in neural precursors: an essential mechanism for sense organ development that is regulated by Notch signaling

Article Abstract:

The development of sense organs requires the ectodermal cellular process involving enhancers and proneural proteins. The enhancers promote proneural protein accumulation in ectodermal cells and mediate self-stimulation. Other cells are exempt from this process due to the Notch signaling, which blocks the self-stimulation activity by antagonizing the enhancer action on the proteins.

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Presynaptic establishment of the synaptic cleft extracellular matrix is required for post-synaptic differentiation

Article Abstract:

A study is undertaken to observe the importance of glutamatergic synapses for shaping neural circuits for development. Findings reveal that MTG is secreted from the presynaptic terminal to shape the extracellular synaptic cleft domain, which in turn functions to mediate transynaptic signals required for post-synaptic development.

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