Dissecting the regulatory circuitry of a eukaryotic genome

Article Abstract:

Genes whose expression relies on the functions of primary components of the transcription initiation mechanism in yeast were identified through genome-wide expression analysis. Components of the RNA polymerase II holoenzyme, the general transcription factor TFIID, and the SAGA chromatin modification complex were observed to be involved in expression of distinct sets of genes.

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The core centromere and Sgo 1 establish a 50-kb cohesin-protected domain around centromeres during meiosis I

Article Abstract:

Study is conducted to show that, Sgo 1, a protein required for protecting centromeric cohesins from removal during meiosis I, localizes to cohesin-associated regions at the centromere and the 50-kb region surrounding it. It is shown that the 50-kb Sgo 1-binding domain is the chromosomal region where cohesions are protected from removal during meiosis I.

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Core transcriptional regulatory circuitry in human embryonic stem cells

Article Abstract:

Genomescale location analysis is used to identify the target genes of transcription factors OCT4, SOX2, and NANOG regulators in vivo. The result provides new insights into the transcriptional regulation of stem cells and reveal how OCT4, SOX2, and NANOG contribute to pluripotency and self-renewal.

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