Displacement of sequence-specific transcription factors from mitotic chromatin

Article Abstract:

Sequence specific transcription factors are displaced from promoter sequences and bulk chromatin during inhibition of hsp70 promoter transcription during mitosis. Analysis of the relation between transcription factor displacement and chromatin condensation shows that mitotic repression of transcription could be due to chromatin structure. The hsp70 promoter is may become disorganized in a canonical nucleosome structure in mitotic chromatin by retention of DNase I hypersensitivity.

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Cell cycle-regulated histone acetylation required for expression of the yeast HO gene

Article Abstract:

Histone acetylation regulated by the cell cycle is necessary for expression of the HO gene in yeast. Chromatin immunoprecipitation assays have been used to study the role of each of the trans-acting factors seen in the expression of the yeast HO gene in late G(sub.one) of the cell cycle in establishing a cell cycle-regulated domain of histone acetylation around the HO upstream regulatory region.

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Global role for chromatin remodeling enzymes in mitotic gene expression

Article Abstract:

Research demonstrates that gene expression in eukaryotes is regulated by chromatin remodeling enzyme SWI/SNF and histone acetyl transferase Gcn5p. Results reveal that the mitotic chromatin is in a condensed form and that SWI/SNF and Gcn5p mediate their expression.

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