Directional sensing requires G(beta)(gamma)-mediated PAK1 and PIX(alpha)-dependent activation of Cdc42

Article Abstract:

Research has been conducted on G(beta)(gamma), PAK-associated guanine nucleotide exchange factor (PIX(alpha)), Cdc42 and p21-activated kinase (PAK). The authors describe the signaling mechanism involving G(beta)(gamma), PIX(alpha), Cdc42 and PAK, and they suggest that G(beta)(gamma) binds PAK1 and activates Cdc42 via PAK-associated PIX(alpha), and that in turn Cdc42 activates PAK1.

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Arp2/3 complex: advances on the inner working of a molecular machine

Article Abstract:

The authors review the publications on the structure and function of the Arp2/3 complex. The topics of interest include the crystal structure, the cryo-EM structure and the reconstruction of the complex from the subunits.

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Journey to the center of the cell

Article Abstract:

The author reviews the publications on the mechanisms used by the pathogenic human viruses to cross the plasma membrane. The topics of interest include retroviruses, adenoviruses, herpes viruses and influenza viruses.

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