Article Abstract:
Studies of intracellular signal transduction pathways indicate that dimerization modulates the activities of many components of the transduction pathways. Oligomerization or dimerization occurs following the association of cytokines, growth factors, polypeptide hormones or growth inhibitors with their receptors and prior to receptor autophosphorylation on a conserved tyrosine residue inside or outside the kinase domains. Homodimeric complex formation between two catalytically active subunits or heterodimeric complex formation between one inactive and one active subunit results from the dimerization of kinase receptors after ligand binding.
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Article Abstract:
Dorsal root ganglia and sciatic nerve of the peripheral nervous sytem (PNS) were studied to examine the expression of platelet-derived growth factor (PDGF) and and PDGF alpha- and beta-receptors. High level expression of PDGF were detected in neonatal rat dorsal root ganglia and sciatic nerve. The receptors, on the other hand, were highly expressed in neonatal rat PNS. The findings indicate that PDGF play a role in the development of the PNS and in maintenance of peripheral neurons.
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Article Abstract:
Immunocytochemical studies and analysis of segmental plate mesoderm grafts from cervical and brachial levels and vice versa confirm that the asymmetry in avian dorsal root ganglia (DRG) size during gangliogenesis is due to the presence of excessive paraxial mesoderm and enhanced DRG growth at brachial levels. The mesodermal microenvironment of DRG at the two axial levels causes variations in the number of cells at each level.
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