Candida albicans proteinases: resolving the mystery of a gene family

Article Abstract:

This review elucidates expression and regulation of the virulence factors in Candida albicans, particularly the aspartic proteinases belonging to the SAP family. Data show that the Sap isoenzymes mediate a variety of functions in vivo with individual proteinases expressing at different times and stages of the infection process.

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Candida albicans secreted aspartyl proteinases in virulence and pathogenesis

Article Abstract:

The authors review the publications on Candida albicans secreted aspartyl proteinases. The topics include pathogenesis and virulenve of Candida albicans, molecular and biochemical properties of Candida's secreted aspartyl proteinases, and functional genomics and Candida.

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Differential regulation of SAP8 and SAP9, which encode two new members of the secreted aspartic proteinase family in Candida albicans

Article Abstract:

Candida albicans is an opportunistic pathogen secreting aspartic proteinases (Saps). There are seven identified genes encoding Saps (SAP1-7), but there is evidence to suggested there are further SAP genes. Two new genes, SAP8 and SAP9 have been isolated following screening of a C. albicans LambdaEMBL3 genomic library. SAP8 mRNA was preferentially expressed in yeasts and SAP9 was found to encode an aspartic proteinase.

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