Differential distribution of cAMP receptors cAR2 and cAR3 during Dictyostelium development

Article Abstract:

The cellular slime mold Dictyostelium undergo signal transduction via a family of G protein-coupled receptors for proper development. Differential spatial and temporal distribution of cAMP receptor subtypes (cAR) such as cAR2 and cAR3 using double immunofluorescence and expression of transformants showed that both receptors are expressed and distributed in a nonoverlapping pattern. cAR2 was expressed at the anterior, prestalk cells while cAR3 was expressed throughout the organism, suggesting that these receptor subtypes may result in distinct signaling mechanisms in the organism.

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Regulation of dictyostelium adenylylcyclases by morphogen-induced modulation of cytosolic pH or Ca2+ levels

Article Abstract:

Experimental studies on the influence of weak acids and bases on the activities of ACA and ACG, two adenylylcyclases and cAMP secretion reveal that the pH dependence of ACA and ACG regulate the weak acid influences on their activity. Weak bases such as ammonia do not regulate cAMP concentrations, while they inhibit ACG and ACA activities.

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Evolution of size and pattern in the social amoebas

Article Abstract:

The construction of a systematic framework to study causal relationships between genotypic and phenotypic change during evolution of the social amoebas are discussed.

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