Article Abstract:
Multilocus enzyme electrophoresis was used in the analysis of 80 nonencapsulated Haemophilus influenzae isolates from patients with meningitis, otitis, chronic bronchitis and cystic fibrosis. Isolates were also recovered from healthy carriers. Genetic distribution of acute disease isolates was concluded as not random over the five electrophoretic types, although the genetic diversity within the groups was not different. The effect of bacterial persistence in the host on the genetic diversity of H. influenzae was also discussed.
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Article Abstract:
Haemophilus influenzae causes upper and lower respiratory tract infections. The entire genome sequence of H. influenzae Rd has recently been determined. The transposon Tn916 has been evaluated as a tool for generalized mutagenesis of the H. influenzae genome. 16 putative target sites were identified, and a new consensus sequence was derived using the observed nucleotide sequences. The curve-twist-curve DNA topology of the sequence is common to all Tn916 integration sites.
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Article Abstract:
Phase variation in H. influenza fimbriae is governed at the transcriptional stage of two divergently oriented genes, the hifA (major fimbrial subunit) and the hifB (fimbrial chaperone subunit). The bidirectional regulation of hifA and hifB transcriptions originates from the clustering of the hifA and hifB promoter regions, and functions due to variations in the length of the repetitive sequence of TA units in the DNA backbone.
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