Article Abstract:
Research was conducted to examine mechanisms for immune tolerance that operate during the early bone marrow stages of B lymphocyte cell development. Several antibodies were utilized in the study, including, goat anti-mouse IgM-FITC, anti-mouse CD21 7E9-biotin and goat anti-mouse IgM-PE. Results indicated that cycling, interleukin-7 (IL-7) responsive BCT Tg cells could be induced to increase levels after specific antigen stimulation and IL-7 withdrawal.
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Article Abstract:
There are two phases of B lymphocyte development, the antigen-independent phase and selective expansion of B cells. The B cell antigen receptor (BCR) acts as a mediator for the B lymphocyte response to foreign antigen. The full composition of the BCR predicted by Burnet was elucidated after several decades. Lam and colleagues have demonstrated the requirement for maintained BCR expression enabling a mature B cell to persist.
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Article Abstract:
A study was conducted to analyze a possible role for BCL10 in male germ cell tumors and lymphoma pathogenesis. Mutation analysis of the coding region was carried out in a panel of germ cell tumors, lymphomas and follicular lymphomas. Results indicated that the lack of mutation in the BCL10 coding region may not exclude it as a deleted tumor suppressor gene. Other genetic or epigenetic mechanisms can silence gene expression.
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