Delineation of key amino acid chains and peptide domains for antimicrobial properties of divercin V41, a pediocin-like bacteriocin secreted by Canobacterium divergens V41

Article Abstract:

A study has revealed that antilisterial peptide Divercin V41, produced by Carnobacterium divergens V41, is homologous to pediocin PA-1 and contains two disulfide bonds. Such compounds have been found to useful in human applications and may provide new approaches for dealing with antibiotic-resistant bacteria. Membrane-active peptide cationicity is important for membrane insertions since these substance interact strongly with anionic membrane phospholipids.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

(Omega)-amino acid:pyruvate transaminase from alcaligenes denitrificans Y2k-2: a new catalyst for kinetic resolution of (beta)-amino acids and amines

Article Abstract:

Selective enrichment and screening of soil samples containing (omega)-amino acid:pyruvate transaminase activity was undertaken for obtaining alcaligenes denitrificans Y2k-2 and kinetically resolve aliphatic (beta)-amino acid and form the clone of the corresponding structural gene (aptA). The study resulted in the characterization of the basic properties of a new L-stereospecific (omega)-APT.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

Binding of pediocin PA-1 with anionic lipid induces model membrane destabilization

Article Abstract:

A study on the effects of pediocin PA-1 on model membranes is reported. The findings show that the association with the membrane interface of dimyristoylphosphatidylcholine (DMPG) does not affect the conformation of the peptide, the adsorption inducing a more folded structure.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code: