Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2

Article Abstract:

H19 and Igf2 imprinting require differentially methylated sequences of H19. Mice with a 1.6-kb targeted deletion of the differentially methylated domain (DMD) have been studied for allelic expression of H19 and Igf2, a linked but oppositely imprinted gene. When the DMD deletion is inherited paternally, H19 is activated and expression of Igf2 is diminished. Maternal transmission of the mutation is associated with reduced expression of H19 and activation of Igf2.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

Transmission of modified nucleosomes from the mouse male germline to the zygote and subsequent remodeling of paternal chromatin

Article Abstract:

A study on paternal chromatin content directly after gamete fusion and the transference of nucleosomes from male germ line to zygote in mice is studied.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

X-tra! X-tra! news from the mouse X chromosome

Article Abstract:

A study on the phenomenon of X chromosome inactivation, where in one of the female X chromosomes becomes inactive in mammals like mice is presented.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code: