Degradation of mRNA in eukaryotes

Article Abstract:

More than one pathway exists for the degradation of mRNA, but deadenylation or shorting of poly(A) tails appears to be a default pathway that applies to some extent to all polyadenylated mRNAs. Deadenylation may be followed by decapping and 5' to 3' decay or by 3' to 5' decay. In addition, there are mechanisms that apply to specific mRNA classes or individuals, such as deadenylation-independent capping and sequence-specific endonucleolytic cleavage. Decay rate is also affected by cis-acting sequences, while other factors may affect turnover of mRNA.

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General translational repression by activators of mRNA decapping

Article Abstract:

The decapping activators Dhh1p and Pat1p are identified as functioning as translational repressors and facilitators of processing body formation. The results identify a broadly acting mechanism of translational repression that targets mRNAs for decapping and functions in translational control.

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Control of translation and mRNA degradation by miRNAs and siRNAs

Article Abstract:

The possible mechanisms by which exogenous micro RNAs (miRNAs) and short interfering RNAs (siRNAs) control translation and degradation of mRNA is discussed. It is found that miRNAs and siRNA, target mRNA to the general eukaryotic cytoplasm for mRNA decay and translation control.

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