Degradation of carboxy-terminal-tagged cytoplasmic proteins by the Escherichia coli protease HflB (FtsH)

Article Abstract:

The ATP-dependent zinc protease HflB and Clp proteases recognize tail-specific pathways and are involved in the process of removing abnormal cytoplasmic proteins in Escherichia coli. HflB degrades four unstable derivatives, three with nonpolar pentapeptide tails and one with the SsrA tag. HflB can compensate loss of ClpP by overproducing.

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Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5(super -/-) mice

Article Abstract:

Netherton syndrome (NS) is a human autosomal recessive skin disease caused by mutation in the SPINK5 gene, which encodes the putative proteinase inhibitor LEKTI is studied. The phenotype is a consequence of desmosomal fragility associated with premature proteolysis of corneodesmosin, an extracellular desmosomal component.

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Defects in regulation of apoptosis in caspase-2-deficient mice

Article Abstract:

Caspase-2's role as a positive or negative cell death effector is defined by the cell lineage and stage of development. Experiments with caspase-2-deficient mice showed the oocytes to be resistant to death where they had been given chemotherapeutic drugs. However, cell death of motor neurons was active.

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