Transcriptional healing

Article Abstract:

Research has been conducted on DNA chemical structure. The effects of DNA injury on transcription machinery have been investigated.

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DNA damage triggers nucleotide excision repair-dependent monobiquitylation of histone H2A

Article Abstract:

Chromatin changes within the context of DNA repair remain obscure, however, it is shown that DNA damage induces monoubiquitylation of histone H2A in the vicinity of DNA lesions. Ultraviolet (UV)- exposure of human cells causes a significant nucleotide excision repair (NER)-dependent monoubiquitylation of H2A and occurs after the incision of the damaged strand and this forms part of the cellular response to UV damage and suggests a role of this modification in DNA repair-induced chromatin modeling.

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Defective transcription-coupled repair in cockayne syndrome b mice is associated with skin cancer predisposition

Article Abstract:

The correlation between defective transcription-coupled repair in nucleotide excision repair disorder Cockayne syndrome B (CSB) and skin cancer susceptibility was analyzed by using a mouse model which mimicked a truncation in the CSB(ERCC6) gene of a CSB human patient thus, rendering it transcription-coupled repair deficient also. Both TCR deficient humans and mice expressed photosensitivity. Mice have a higher risk of skin cancer due to a weak global genome repair system, in contrast to humans who have reportedly lower risk due to a more potent global genome repair system.

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