Article Abstract:
Gene targeting was used in mice to look at the function of Scp2, encoding sterol carrier protein-2 (SCP2; a peroxisomal lipid carrier) and sterol carrier protein-x (SCPx; a fusion protein between SCP2 and a peroxisomal thiolase). Peroxisome proliferation, hypolipidemia, poor body weight control, neuropathy and marked changes in gene expression occurred with no SCP2 and SCPx. Catabolism of methyl-branched fatty acyl CoAs was cut back. Accumulation of tetramethyl-branched phytanic acid, a fatty acid, in spc2(-/-) mice occurred. Gene disruption brought on poor import of phytanoyl-CoA into peroxisomes and to unsatisfactory thiolytic cleavage of 3-ketopristanoyl-CoA.
User Contributions:
Comment about this article or add new information about this topic:
Article Abstract:
A study was conducted to demonstrate that Short Vegetative Phase (SVP) gene in Arabidopsis plays an important role in the response of plants to ambient temperature changes. SVP controls flowering time by negatively regulating the expression of a floral integrator, Flowering Locus T (FT) via direct binding to the CArG motifs in the FT sequence which is suggested to be one of the molecular mechanisms that modulate flowering time under fluctuating temperature conditions.
User Contributions:
Comment about this article or add new information about this topic:
Article Abstract:
A study to show that, the Neurospora protein VVID (VVD) buffers the circadian system against temperature fluctuations is presented. Result show that temperature compensation of clock-controlled output is a key factor in maintaining temperature compensation of the entire circadian system.
User Contributions:
Comment about this article or add new information about this topic: