Article Abstract:
DWnt-2 is a secreted glycoprotein related to wingless in Drosophila, in which cells of the gonad and the genital disc must be given fates that are sex-specific. DWnt seems to be a signal necessary for cell fate determination and morphogenesis in the male reproductive tract as it develops. DWnt-2 is expressed in parts of the male genital disc and gonad. They are sites of contact with muscle precursor cells. That indicates that secreted DWnt-w protein signals for the migration or attachment of the cells.
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Article Abstract:
The Drosophila frizzled 2 can stabilize Wingless (Wg) protein because of the high levels of Wg receptor which allow such protein to reach cells beyond its site of synthesis. The creation of a gradient decreasing Wg stability which is moving toward the dorsal/ventral boundary can be attributed to the repression of Drosophila frizzled 2 expression by Wg signaling. Such Drosophila frizzled is vital for the normal shape of Wingless morphogen gradient and to the response of cells to Wg signal.
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Article Abstract:
Experimental analysis of the in vivo expression domains of Drosophila's DWnt-3 protein with the help of region-specific antisera indicates that the commissural axon tracts of the central nervous system (CNS) are disrupted due to DWnt-3 gene expression. This suggests that a protein encoded by the DWnt-3 gene influences CNS of Drosophila by depositing in the axon tracts of the CNS. The wingless gene is not substituted by this DWnt-3 gene.
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