DNA single-strand break repair and spinocerebellar ataxia

Article Abstract:

The author reviews the publications on DNA single-strand break repair. The topics of interest include the studies of relationship between mutations in putative human DNA single-strand break repair and hereditary spinocerebellar ataxia, and the links between neurodegenerative disorders and spinocerebellar ataxia.

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XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair

Article Abstract:

The mammalian DNA single-strand break repair is mediated by XRCC1 protein by interacting with human polynucleotide kinase and DNA polymerase-beta and DNA ligase III. Data indicate that XRCC1 interaction with polynucleotide kinase stimulates DNA kinase and DNA phosphatase activities.

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Molecular basis of phosphorylation-induced activation of the NADPH oxidase

Article Abstract:

Research has been conducted on cytoplasmic p40-p47-p67 (super)phox complex. The results of structural and biochemical data demonstrate that phosphorylation of p47 (super)phox activates molecular switch which relieves inhibitory intramolecular interaction.

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