DNA deamination mediates innate immunity to retroviral infection

Article Abstract:

Research indicates that built-in immunity to retroviruses results from DNA deamination as shown by the incorporation of DNA deaminase into virions during viral development triggering viral destruction. Data show that the enzyme is involved in a massive deamination of deoxycytidine to deoxyuridine within the retroviral cDNA strand.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

Extracellular crosstalk: when GDNF meets N-CAM

Article Abstract:

The authors discuss the study on a receptor for glial cell line-derived neurotrophic factor. The topics of interest include RET-dependent glial cell line-derived neurotrophic factor signaling and the role of glial cell line-derived neurotrophic factor-neural cell adhesion molecule pathway.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

HIV-1 sequence variation: drift, shift, and attenuation

Article Abstract:

The authors review the publications on the retrovirus human immunodeficiency virus type-1 (HIV-1) in humans. The diversification of the HIV-1 strains have been investigated and the technical advances made in DNA sequencing genome plasticity are discussed.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code: