Article Abstract:
The three main issues addressed by several studies on DNA damage and replication checkpoints are discussed. The first involves the basic molecular anatomy of the checkpoint protein interaction that is responsible for the signal arrest and transcriptional induction of repair genes, The second concerns several interactions between checkpoint controls and DNA repair and replication. The last concerns the roles of checkpoints in preserving genomic stability.
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Article Abstract:
DNA nonhomologous end-joining (NHEJ) is a predominant pathway of DNA double-strand break repair in mammalian cells, and defects in it cause radiosensitivity at the cellular and whole-organism levels. It is shown that XRCC4-like factor (XLF) directly interacts with the XRCC4-Ligasse IV complex in vitro and vivo and that siRNAA-mediated down regulation of XLF in human cell lines leads to radiosensitivity and impaired NHEJ.
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Article Abstract:
A study was conducted in response to DNA damage where mammalian cells trigger the p53 dependent transcriptional induction of factors that regulate DNA repair, cell-cycle progression, or cell survival. The results showed heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a new HDM2 target and plays key roles in coordinating transcriptional responses to DNA damage by serving as a cofactor for p53.
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