Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly

Article Abstract:

A study to demonstrate the mitochondrial function for Ecsit (an evolutionary conserved signaling intermediate in Toll pathways) in the assembly of mitochondrial complex I (NADH: ubiquinone oxidoreductase) was conducted. The observation supports the function for Ecsit in the assembly or stability of mitochondrial complex I which possibly links assembly of oxidative phosphorylation complexes to inflammatory response and embryonic development.

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Rearrangement of competing U2 RNA helices within the spliceosome promotes multiple steps in splicing

Article Abstract:

The splicing of nuclear pre-messenger RNA is dependent on the spliceosomal progression cycle of U2 stem helices- stem IIa and IIc elements of small RNA. The mutations inducing splicing defects reveal the presence of competing stem IIa in the first step of splicing.

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U2 toggles iteratively between the stem IIa and stem IIc conformations to promote pre-mRNA splicing

Article Abstract:

The pre-mRNA splicing is promoted by binding of U2 snRNP to pre-mRNA. The U2 switches in between the stem IIa and stem IIc of RNA to impair the ligation of the two segments and facilitate splicing.

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