Article Abstract:
A functional association with cytoplasmic coat proteins of the ARF and COP-I families affects the activity of endosomes, formed during receptor-mediated endocytosis. GTP-gamma-S activates the association, while brefeldin A inhibits it. A mutation in the epsilon-COP gene disrupts the sorting activity of the endosomes, suppressing the recycling of low density lipoproteins. Antibodies against beta-COP inhibit the formation of endosomes and prevent the entry of vesicular stomatitis virus into the endocytic pathway.
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Article Abstract:
A study was conducted to determine the physiological function of the coat protein termed TACO in macrophage phagosomes. Results indicate that mycobacteria in macrophages lacking TACO proteins are readily transported to lysosomes and subsequently, degraded. On the other hand, macrophages with sufficient TACO proteins are observed to support the presence of mycobacteria. Hence, TACO proteins are found to play a vital role in the intracellular survival of mycobacteria.
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Article Abstract:
A chimera of the temperature-sensitive glycoprotein of vesicular stomatitis virus and green fluorescent protein (ts-G-GFPct) was used to visualize exocytic transport from the endoplasmic reticulum (ER) to the Golgi complex. Ts-G-GFPct concentrates into COPII-positive structures close to the ER, on shift to permissive temperature, forming an intermediate compartment containing ERGIC-53. This indicates a sequential mode of COPII and COPI action.
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