Cyclin D1 provides a link between development and oncogenesis in the retina and breast

Article Abstract:

Mice with deficient cyclin D1 show reduced body size, reduced viability, symptoms of neurological defects and cancerous developments in the retina and the breasts. The retinas of the mice kept under observation demonstrated a striking reduction in cell number due to proliferative failure during embryonic development. In adult mutant females, the breast epithelial cells fail to undergo the massive proliferative changes related with pregnancy despite normals levels of ovarian steroid hormones.

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Cyclin E ablation in the mouse

Article Abstract:

Results reveal that E type cyclins are not strictly essential for mouse development, in contrast to its role in other species. Cyclin E-deficient cells proliferate under cell cycling conditions but are unable to reenter the cell cycle S phase. Data indicate that cyclin E-deficient cells do not incorporate MCM proteins into DNA replication origins during cell cycle and are resistant to oncogenic transformation.

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Mouse development and cell proliferation in the absence of D-cyclins

Article Abstract:

Studies done on the requirement for D-type cyclins in mouse development and in proliferation by generating mice lacking all D-cyclins are reported. Findings of the study reveal the presence of alternative mechanisms that allow cell cycle progression in a cyclin D-independent fashion.

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