Article Abstract:
A study was conducted to determine whether similar mechanisms of terminal differentiation of lens fiber cells can be used in testing for the presence of cyclin B/p34 complexes and p34-associated histone kinase activity in differentiating lens fiber cells. Reverse transcription and polymerase chain reaction revealed an amplified cyclin B product and in situ hybridization revealed cyclin B mRNA in nucleated lens fiber cells, while immunoblotting confirmed presence of the complexes in different proteins. These results suggest that cyclin B/p34 and p34-associated histone kinase activity are present in differentiating lens fiber cells.
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Article Abstract:
Studying the giant fibre system (GFS) is a way to study one of the key issues of developmental neurobiology, namely, how cells build the synapses that are the basis of neuronal circuits. Another way is to study the defects in behavioral mutants. Some flies carrying certain shak-B alleles have abnormalities in some of the synapses of the GFS. The shak-B gene has two very different roles in development, which are tested and discussed here.
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Article Abstract:
The wingless (wg) gene appears to have an autoregulatory function, distinct and separable from paracrine regulation through the engraled gene (en), in the wild type embryo of Drosophila. The asymmetric patterning of epidermal cell types in the larval cuticle depends on delayed, localized wg expression. En can induce expression from the endogenous wg gene only in immediate neighboring cells that have been exposed to wg.
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