Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic differentiation of chondrocytes

Article Abstract:

The role of cGKII as a molecular switch, coupling the cessation of proliferation and the start of hypertrophic differentiation of chondrocytes through attenuation of Sox9 function is studied. The cGKII attenuated the Sox9 functions to induce the chondrogenic differentiation and to inhibit the hypertrophic differentiation of chondrocytes and the attenuation of Sox9 was due to the cGKII inhibition of nuclear energy.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

A MyoD-generated feed-forward circuit temporally patterns gene expression during skeletal muscle differentiation

Article Abstract:

In the skeletal myogenesis, gene expression is initiated by MyoD and includes the expression of specific Mef2 isoforms and activation of the p38 mitogen-activated protein kinase is studied. The p38 activity facilitates MyoD, Mef2 binding at a subset of late activated promoters, and the binding of Mef2d recruits Pol II.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

Essential and separable roles for syndecan-3 and syndecan-4 in skeletal muscle development and regeneration

Article Abstract:

Syndecan-3(super -/-) mice exhibit a novel form of muscular dystrophy characterized by impaired locomotion, fibrosis, and hyperplasia of myonuclei and satellite cells. The data reveals that the surrounding environmental is critical for satellite cell proliferation and differentiation.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code: