Article Abstract:
A cream yellow coat color had been found in a breeding colony of albino mouse of strain CAL20. Genetic studies showed that the cream yellow coat color phenotype was regulated by a single recessive mutant gene on chromosome 13. The cream yellow hair was also found to have more fatty acid than normal hair and that the color was due to an unusual lipid metabolism. The locus was named cream fur locus and was given the symbol crf. It was also observed that recombination frequencies near the area of the crf locus were very different between male and female meiosis.
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Article Abstract:
Genomic imprinting causes functional specialization of the parental genomes during development, resulting in offspring inheriting just one active copy of a gene. The molecular imprinting mechanism is not known but it is thought that the genome specialization is established during gametogonesis. An interspecies mRNA phenotyping method to detect allele-specific gene expression in mice and to identify candidate imprinted genes in mammals is described.
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Article Abstract:
Genetic profile analysis reveals that a new mutation rather than genetic contamination leads to the phenotype of white, pink-eyed mouse among DBA/2N mice. This phenotype exhibits pleiotropic effects. They include white color due to the absence of melanocytes, small malformed eyes with reduced pigment in retina, choroid and iris, abnormally thin stria vascularis of the inner ear, and reproductive defects in females.
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