Coupling of a replicative polymerase and helicase: a tau-DnaB interaction mediates rapid replication fork movement

Article Abstract:

The interaction between the tau subunit of the replicative polymerase and the replication fork DNA helicase (DnaB) is demonstrated to be involved in the fast replication fork movement in Escherichia coli. DnaB's translocation rate is ten times multiplied after a tau-DnaB link is developed. Findings indicate the presence of both a physical and communications connection between the DNA polymerase and the primosome, the two main replication components.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

The DNA polymerase III holoenzyme: an asymmetric dimeric replicative complex with leading and lagging strand polymerases

Article Abstract:

Research demonstrates that formation of DNaX complexes in the presence of ATP on primed DNA is mediated by the DNA polymerase III holoenzyme. Results show that the holoenzyme is an intrinsically asymmetric dimer with distinguishable leading and lagging strand polymerases.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

Structure of the replicating complex of a pol alpha family DNA polymerase

Article Abstract:

The human pol alpha family ternary complex consiting of RB69 DNA polymerase complexed with primer-template DNA and a deoxynucleoside triphosphate exhibits differences and similarities to other DNA polymerases.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code: