Correction of the CF defect by curcumin: Hypes and disappointments

Article Abstract:

Curcumin, a non-toxic natural product and major constituent of turmeric spice, corrected the cystic fibrosis (CF) defects in deltaF508 CF mice. Although hopes were raised that curcumin might provide an efficient treatment for most CF patients, skepticism is growing since subsequent studies fail to reproduce these initial exciting results.

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Are there non-catalytic functions of acetylcholinesterases? Lessons from mutant animal models

Article Abstract:

Many studies led to the hypothesis that acetylcholinesterase (AChE) and the closely related enzyme butyrylcholinesterase may play other non-hydrolytic roles during development. Comparison of data from in vivo studies performed on invertebrate and vertebrate genetic models is discussed.

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Distributed robustness versus redundancy as causes of mutational robustness

Article Abstract:

The evidence suggesting that robustness is equally or more important for mutational robustness than gene redundancy is discussed. The evidence showing the causes of robustness comes from the functional divergence of redundant genes as well as from large-scale gene deletion studies.

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