Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins

Article Abstract:

A cooperative interaction between the DNA binding domains of the myocyte enhancer factor-2 (MEF2) and the myogenic basic helix-loop-helix (bHLH) proteins increases muscle gene expression. MEF2 binds to the E box target regions of bHLH. The stimulation of gene expression in fibroblasts requires a transactivation domain in either MEF2 or BHLH. The probable mechanisms of muscle gene activation are discussed.

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Control of myoblast fusion by a guanine nucleotide exchange factor, loner, and its effector ARF6

Article Abstract:

Research reveals that muscle development in Drosophila requires myoblast fusion mediated by the loner gene, which encodes a guanine nucleotide exchange factor. Data show that loner is localized to subcellular sites of fusion and acts in coordination with cell surface fusion receptors by recruiting the other essential factor GTPase ARF6 involved in myoblast fusion.

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A unified nomenclature system for the Drosophila odorant receptors

Article Abstract:

This article reports on the odorant receptor genes of Drosophila coding transmembrane domain receptor proteins that are expressed in the olfactory receptor neurons. A total of 60 odorant receptors are currently identified.

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