Control of liver cell fate decision by a gradient of TGF(beta) signaling modulated by Onecut transcription factors

Article Abstract:

A study is conducted to show that a gradient of activin/TGF(beta) signaling controls hepatoblast differentiation. It is found that in the absence of Onecut transcription factors, the shape of the activin/TGFB signaling is perturbed and the hepatoblasts differentiate into hybrid cells that display characteristics of both hepatocytes and biliary cells and therefore, a gradient of activin/TGF(beta) signaling modulated by Onecut factors is required to segregate the hepatocytic and the biliary lineages.

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The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs

Article Abstract:

The interaction of Upf1p and peptidyl release factors is critical for the putative surveillance complex formation and the degradation of aberrant mRNAs. It also improves translation termination and ensures that there is no premature translation. This nonsense-mediated mRNA decay pathway enables the cell to dispose of meaningless mutations.

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Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells

Article Abstract:

The article presents the findings that demonstrate the importance of finely regulating the activities of mitogen-activated protein kinases during embryonic development for survival of liver cells.

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