Control of dTTP pool size by anaphase promoting complex/cyclosome is essential for the maintenance of genetic stability

Article Abstract:

A study is conducted to demonstrate that thymidylate kinase is recognized and targeted for degradation by anaphase promoting complex /cyclosome-Cdh1(APC/C)-Cdh1)-mediated pathways from mitosis to the early G1 phase, whereas thymidine kinase is targeted for degradation by APC/C-Cdh1 after mitotic exit. It can be concluded that down-regulation of dTTP pool size by the APC/C pathway during mitosis and the G1 phase is an essential means to maintain a balanced dNTP pool and to avoid genetic instability.

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Kinetochore-microtubule interaction during S phase in Saccharomyces cerevisiae

Article Abstract:

A study giving crucial insights into early kinetochore-microtubule interaction that ensures high-fidelity chromosome segregation in the subsequent anaphase is presented. Results show that the centromeres detach from microtubules and move away from a spindle pole for 1-2 minutes during S phase.

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A dynamic, mitotic-like mechanism for bacterial chromosome segregation

Article Abstract:

The role of the Vibrio cholerae ParAI and ParBI proteins in the segregation of chrI is explored. The results have indicated that ParAI forms a dynamic structure that pulls the ParBI-bound chromosome to the pole in a process analogous to anaphase of eukaryotic mitosis.

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