Trio combines with Dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila

Article Abstract:

Trio has been found to combine with the SH2-SH3 adaptor Dock to regulate p21-activated kinase (Pak) activity in Drosophila photoreceptor axon pathfinding. The guanine nucleotide exchange factor (GEF) Trio has been identified and found to be another required part of photorecpetor axon guidance.

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Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons

Article Abstract:

The functional analysis of vilse, a drosophila gene required for Robo repulsion in epithelial cells and axons is described. The results and the genetic interaction experiments with robo, vilse, and rac mutants suggest a mechanism whereby Robo repulsion is mediated by the localized inactivation of Rac through Vilse.

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Control of Drosophila photoreceptor cell fates by phyllopod, a novel nuclear protein acting downstream of the Raf kinase

Article Abstract:

Analysis of phyllopod (phyl) gene in Drosophila shows that it controls the fate of photoreceptor cells in the Drosophila eye and that deletion of phyl gene function causes the transformation of the photoreceptors to extra cone cells. The function of phyl cone cell growth is similar to the Raf pathway function. Ectopic phyl expression is seen during, and influences the conversion of cone cells to R7 cells by the Raf pathway.

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