Article Abstract:
The rates of intralocus recombination were quantified by statistical analysis of DNA sequences of human HLA-A and HLA-B class I MHC loci. Recombination occurred twice as frequently at the B locus than the A locus with B locus recombinants significantly affecting polymorphic sites in the antigen recognition sites. Well-defined allelic lineages in the A locus seem to have persisted prior to the human-chimpanzee divergence in contrast to the B locus. Thus, relatively frequent interallelic recombination has been a feature of long-term evolution of the B locus.
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Article Abstract:
Knotted-1 (KN1) locus mutations are analyzed. These mutations have an impact on the growth patterns of leaves. Tissues which protrude along the lateral veins of the maize leaf and displacement of ligule tissue from the blade and sheath junction mark Kn1-0 mutations. Such mutations emerge from tandem duplication of 17kb, where repetitions cover the total KN1 transcription unit. Mutant phenotypes can be decreased by inserting mutator (Mu) transposable elements at the junction.
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Article Abstract:
The M26 mutation is widely recognized as a meiotic recombination hot spot in Schizosaccharomyces pombe. The hot spot, also a single base substitution, is located within the ade6 open reading frame near the 5' end. Although M26 accounts for both homologous and ectopic recombination in meiosis, it fails to catalyze mitotic recombination. An active M26 decreases activity for the ura4-aim novel recombination hot spot.
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