Connecting cancer to the asymmetric division of stem cells

Article Abstract:

A study demonstration that the cell-fate determinant Brain Tumor (Brat) suppresses self-renewal in one of the daughter cells that arises from the asymmetric division of a neural stem cell is presented. The findings suggest a mechanism by which loss of polarity in stem cells might lead to tumorigenesis.

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Bacterial mitotic machineries

Article Abstract:

Fundamental new insight into the molecular mechanisms behind plasmid and chromosome segregation in prokaryotic cells is reviewed. A study is conducted to show how prokaryotic actin homologs form mitotic machineries that segregate DNA before cell division.

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Coordination of cell division and chromosome segregation by a nucleoid occlusion protein in Bacillus subtilis

Article Abstract:

The identification of a specific effector of nucleoid occlusion in Bacillus subtilis is discussed. YyaA contributes to the correct placement of the division site and reduces the risk of chromosome damage during division.

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