Conjugative transposons: an unusual and diverse set of integrated gene transfer elements

Article Abstract:

Conjugative transposons take part in spreading antibiotic resistance genes in gram-positive cocci, and other gram-positive and gram-negative bacteria. Conjugative transposons are integrated DNA elements that can dissociate themselves and reintegrate into the same cell or into another cell by conjugation. The genes that confer resistance do not need to be present on the transposon to be transferred. The host range of conjugative transposons is wide and they are capable of mobilizing plasmids and other integrated elements. The method of excision and integration is different from that found in regular transposons.

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Identification and characterization of conjugative transposons CTn86 and CTn9343 in Bacterroides fragilis strains

Article Abstract:

The conjugative transposons of Bacterroides fragilis namely, CTn86 and CTn9343 have shown similarity in their basic structures, except in the presence of an extra 7-kb region in CTn86. The DNA hybridization studies show flanking elements of pathogenicity island (PAI) similar to CTn86 in 36% strains and that is similar to CTn9343 in 36% where as the remaining strains have dissimilar structures.

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Genetic screen for regulatory mutations in Methanococcus maripaludis and its use in identification of induction-deficient mutants of the euryarchaeal repressor NrpR

Article Abstract:

Methanococcus maripaludis is used to determine the structural basis for the induction of NrpR-regulated genes. Two sites are identified in both NrpR domains in Methanococcus maripaludis that participate in induction through their role in the 2-oxoglutarate response.

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