Article Abstract:
The expression of Delta (Dl) protein in germ-line and follicle cells during the oogenesis of Drosophila melanogaster was discussed. The expression was correlated with different morphogenetic defects such as germ-line cell necrosis, multiphasic embryonic arrest of fertilized eggs and failure of stalk formation within the germarium. In addition, the mutation that caused context-dependent defects in Dl function was identified. The Dl protein showed similar spatial and temporal expression patterns when compared with the Notch protein. However, these patterns did not coincide in different stages of oogeneis which suggested that the actions are related to specification of cell fates during oogenesis
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Article Abstract:
Identification of target genes controlled by the Ultrabithorax (UBX) homeoproteins in Drosophila melanogaster involves the use of a novel method based on the transcriptional activation of a selectable reporter in yeast cells. Screening of 15% of the Drosophila genome enables the recovery of various DNA fragments associated with the activation by UBX isoform Ia. Many fragments are single-copy sequences, which reside close to a transcription unit. Transcriptional regulators in diverse organisms can be studied by slightly modifying the approach.
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Article Abstract:
Four mutations in the Drosophila serendipity (sry) delta finger protein are characterized. The mutations, induced by ethyl methanesulfate, are all lethal mutations varying in their potencies which occur late in embryonic development, during the first larval instar or during pupation. Studies done on males escaping the lethal effects of the mutation indicate that the gene is essential either in the preservation of viability, normal gonadal development or both.
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