Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression

Article Abstract:

The role of proximal and distal cis regulatory elements in gene expression of Pdx1 required for the production of duodenal gastrointestinal hormone cells and stomach gastrin cells in mice is studied.

author: Wright, Christopher V.E., Fujitani, Yoshio, Boyer, Daniel F., Gannon, Maureen, Powers, Alvin C., Stein, Roland W.
United States, Mice, Embryology, House mouse, Gastrin, Gastrointestinal hormones

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Endodermal expression of Nkx6 genes depends differentially on Pdx1

Article Abstract:

The article compares and contrasts Nkx6 family genes in mice and chickens. Findings indicate genetic requirements for early foregut endoderm.

author: Sander, Maike, Serup, Palle, Pedersen, Jesper K., Nelson, Shelley B., Jorgensen, Mette C., Henseleit, Korinna D., Fujitani, Yoshio, Wright, Chris V.E.
Chickens, Endoderm

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Odd-skipped related 1 (Odd1) is an essential regulator of heart and urogenital development

Article Abstract:

A mouse model is used to delineate the underlying molecular mechanisms for urogenital development and heart morphogensis.

author: Qingru Wang, Yu Lan, Eui-Sic Cho, Maltby, Kathleen M., Rulang Jiang
Heart, Genetic regulation, Morphogenesis, Genitourinary organs, Urogenital system

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subjects list: Research, Genetic aspects, Physiological aspects, Animal embryology, Muridae
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