Article Abstract:
Three proteins, namely, Hedgehog (Hh), Wingless (Wg) and Decapentaplegic (Dpp), are responsible for the growth and patterning of the Drosophila leg. Hh, which is secreted in the posterior cells, induces the dorsal anterior cells to secrete Dpp and the ventral anterior cells to secrete Wg. The complementary patterns of dpp and wg expression are studied. Results indicate that the patterns are maintained by mutual repression, which is essential for normal axial patterning.
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Article Abstract:
A study of the role of protein kinase A (PKA) and hedgehog (hh) signaling in limb development in Drosophila reveals that PKA inhibits irregular wingless (wg) and decapentaplegic (dpp) expression during limb development. hh removes the PKA-induced block, promoting wg and dpp expression. Removal of PKA activity in anterior cells results in the expression of wg and dpp by these cells, leading to the rearrangement of the surrounding wild-type tissue.
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Article Abstract:
Genetic evidence supporting the role of the Patched (Ptc) protein in signal transduction of the Hedgehog family are presented. Using in vivo assays, it is shown that Ptc binds Hh which leads to alterations in cellular behavior. The results also reveal that Ptc inhibits the spread of Hh from the P into the A compartment cells when present at excessively high amounts. A model illustrating Ptc activities is presented.
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