Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene

Article Abstract:

Metastatic variants are characterized with an acquired focal chromosomal amplification that corresponds to a much larger amplification in human metastatic melanomas and the analyses has identified Nedd9, an adaptor protein related to p130CAS, as the only gene within the minimal common region that displayed amplification-associated overexpression. The comparative oncogenomics has helped in the identification and has facilitated the validation of a highly relevant cancer gene governing metastatic potential in human melanoma.

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Role of the INK4a locus in tumor suppression and cell mortality

Article Abstract:

Analysis of mice embryos that were null-mutated at the INK4a locus showed cells developing spontaneous tumors at an early stage. Studies have shown that tumor development is controlled by the cell cycle inhibitor p16(super INK4a). Alterations in the INK4a locus not only affects p16, but also nearby genes that encode for other cyclin-dependent kinases such as p15(super INK4a) and p19(super ARF).

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A genetic screen for candidate tumor suppressors identifies REST

Article Abstract:

An RNAi-based genetic screen for genes that suppress transformation of human mammary epithelial cells is reported. The results implicate REST gene as a human tumor suppressor and provide a novel approach to identifying candidate genes that suppress the development of human cancer.

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